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May 21, 2007
Siemens is the first company to develop complete
ASL solution for non-contrast perfusion imaging
Siemens is the first
company to develop a complete commercial ASL (Arterial Spin
Labeling) solution with the University of Pennsylvania. ASL is
an application which enables perfusion imaging without the use
of contrast agents. With this patent, Siemens will introduce
syngo ASL*, powered by Tim (Total imaging matrix), thereby
allowing a broad range of users in both the
clinical and research settings to get access to this
promising application.
Arterial Spin Labeling (ASL) is an MR
technique using the water in arterial blood as an
endogenous contrast agent to evaluate perfusion non-invasively. It provides
unique insight into human brain perfusion and function physiology
by evaluating cerebral blood flow (CBF). ASL is capable
of high spatial resolution perfusion imaging, making the technique
very appealing in the evaluation of stroke, tumors, degenerative
diseases, epilepsy but also in basic neuroscience, e.g. for
studies of functional CBF changes.
Initially the techniques used
for determining cerebral blood flow were rather invasive and
involved the use of exogenous contrast agents, such as
15O labeled radiotracer in Positron Emission Tomography (PET). With
MRI, brain perfusion studies have been commonly performed using
exogenous Gadolinium-based contrast agents. The principles behind ASL are
quite similar to those utilizing exogenous contrast agents. However,
ASL is completely non-invasive: there is no radiation and
no injection of contrast media necessary.
The Siemens syngo
ASL implementation profits from the Tim technology by being
integrated with Parallel Imaging – which reduces the acquisition
time. In addition, Siemens has integrated its unique 3D
PACE motion correction technique, which increases robustness in clinical
and research use.
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